L-Carnosine 99% 10 grams

L carnosine 99.43%
CAS# 305-84-0

Fibroblasts were once considered to be static and with limited function with in extracellular matrix[ ECM] production. However that has been shown not to be the case. These cells are functionaly and morphologically dynamic with a clear trend towards hetergeneity in various tissues 1 Papillary fibroblasts of the superficial dermis are known to produce more decorin than versican. Decorin is noted for its role in ECM assembly by binding to type 1 collagen fibrils. Versican plays a matrix role in maintaining integrity via hyaluronan modulation.These proteoglycans are also expressed by the deeper reticular fibroblasts.  1Types 1 and 111 collagen are produced by both reticular and papillary fibroblasts in like quantity and ratio. 2 The two collagen types are expressed at a constant ratio in normal adult skin, but shows a marked decrease in cases of abnormal metabolism. Dermal fibroblasts play a crucial role in ECM deposition but also regeneration and repair.

The ECM is the complex within which a diverse array biological and biochemical functions are mediated by specific matrix molecule receptors and cell binding epitopes. The pericellular environment is the physiological niche for cells which not only protects them but further mediates celluar signalling. Metabolism and morphpgenesis are of cells is controlled via the ECM through the storage and release of signaling factors[ growth factors, cytokines]

L carnosine is the most abundant nitrogenous compound in the skeletal muscles and the olfactory lobe of the brain, it is synthesised by carnosine synthetase and catalysed by carnosinase. This is problematic from the persepective of oral supplements carnosine is rapidly broken down with in the body.L-carnosine is noted for various properties including: 1) myosin activation, 2) intracellular buffering of acids, 3) antioxidant activity, 4) prevents formation of advanced glycation end products [AGEs], 5) chelation of  divalent ions and 6)cellular rejuvenation.

L carnosine is able to rejuvenate senescent fibroblasts as was show in the work of McFarland and Holiday 4 , in a dose dependent manner.  The cells showed an increase in population as well as chronological time. Senescent cells were taken from an L carnosine deficient media and placed in an L carnosine rich media where they regained their non senescent properties. This was concluded to be due to the active participation of L carnosine in cellular metabolism.

Nolte SV, Xu W, Rennekampf H, Rodemann HP, Diversity of Fibroblasts-A review on implications for skin tissue engineering. Cells Tissues Organs 2007; 187 (3):1-12
Gron B, StoltzeK, Andersson E, Dabelseen E. Oral fibroblasts produce more HGF and KGF than fibroblasts in response to co-cultrue with keratinocytes. APMIS 2002; 110; 892-8
Sorrell JM, Caplan Al, Fibroblast heterogeneity: more than skin deep. J Cell Sci 1004; 117:667-5
Holliday R, McFarland GA. Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine. Br. J Cancer 1996; 73:996-971


Carnosine inhibits ATP production in cells from malignant glioma.
A possible new role for the anti-ageing peptide carnosine.
Pluripotent protective effects of carnosine, a naturally occurring dipeptide.
Carnosine protects proteins against methylglyoxal-mediated modifications.
Carnosine reacts with a glycated protein.

Appearance: White powder
pH: 5-6.5
Solubility: water
Usage: 1 %
Storage: Dry